MaxRequestWorkers setting

Please let me know that how to fixing MaxRequestWorkers setting? Site doing UP and Down. What you are recommended for MaxRequestWorkers limit? 51103 [Mon Mar 05 01:00:14.270856 2018] [mpm_worker:notice] [pid 4189:tid 139790578227328] AH00297: SIGUSR1 received. Doing graceful restart [Mon Mar 05 01:00:14.359867 2018] [mpm_worker:warn] [pid 4189:tid 139790578227328] AH00315: MaxRequestWorkers of 400 is less than ThreadsPerChild of 2000, increasing to match [Mon Mar 05 01:49:17.135602 2018] [mpm_worker:error] [pid 4189:tid 139790578227328] AH00286: server reached MaxRequestWorkers setting, consider raising the MaxRequestWorkers setting [Mon Mar 05 01:49:21.138610 2018] [mpm_worker:error] [pid 4189:tid 139790578227328] AH00287: server is within MinSpareThreads of MaxRequestWorkers, consider raising the MaxRequestWorkers setting [Mon Mar 05 02:29:08.272959 2018] [mpm_worker:alert] [pid 32492:tid 139790578227328] (11)Resource temporarily unavailable: AH00282: apr_thread_create: unable to create worker thread [Mon Mar 05 02:29:10.275982 2018] [mpm_worker:alert] [pid 30120:tid 139790578227328] (11)Resource temporarily unavailable: AH00282: apr_thread_create: unable to create worker thread [Mon Mar 05 02:29:45.289190 2018] [mpm_worker:alert] [pid 30112:tid 139790578227328] (11)Resource temporarily unavailable: AH00282: apr_thread_create: unable to create worker thread