Should I use the cPanel autoresponder or Gmail autoresponder?

I get many emails that score a 2 on the cPanel spam filter but are indeed spam. Not the end of the world but I wonder: 1. Is it a problem that my cPanel autoresponder email goes out to them? I wonder if I'm hurting my sender reputation by sending autoresponder emails to all of these spam email addresses? 2. If it is an issue, I wonder if I should instead use Gmail's autoresponder functionality? I pull all of my email down to Gmail, and they do a great job of filtering out the spam, so I wonder if setting up an autoresponder within Gmail would be better. Any thoughts? Thank you!