SMTP error from remote mail server after end of data: 550 Message rejected due to user rules.

Hi, I have just noticed that emails that are send from our website or a cron job are no longer reaching the end users. This be the case for a few months already, but we have not been very active. In the result I see this error: ECDHE-RSA-AES256-GCM-SHA384:256 CV=no: SMTP error from remote mail server after end of data: 550 Message rejected due to user rules. We have not made any changes lately, so what could have changed? And how can I solve this? Regards, Jelmer