MySQL 5.6 Optimization Guidance

Hi, Noticing some heavy load on one of our mysql data disks attached to a VM. I'd really appreciate some help. Thanks Here is the my.cnf config we use currently:

[mysqld]
datadir = /data/mysql
query_cache_type=1
max_connections=100
join_buffer_size=1M
myisam_use_mmap=1
myisam_sort_buffer_size=128M
local-infile=0
thread_cache_size=25
key_buffer_size=128M
read_rnd_buffer_size=1M
max_allowed_packet=268435456
open_files_limit=50000
default-storage-engine=MyISAM
log-error="/var/log/mysqld.log"
max_user_connections=30
table_open_cache=7500
max_connect_errors = 100000

Also here is the mysqltuner results:

>>  MySQLTuner 1.3.0 - Major Hayden 
 >>  Bug reports, feature requests, and downloads at /http://mysqltuner.com/
 >>  Run with '--help' for additional options and output filtering
[OK] Currently running supported MySQL version 5.6.16-cll-lve
[OK] Operating on 64-bit architecture

-------- Storage Engine Statistics -------------------------------------------
[--] Status: +ARCHIVE +BLACKHOLE +CSV -FEDERATED +InnoDB +MRG_MYISAM
[--] Data in MyISAM tables: 2G (Tables: 20216)
[--] Data in InnoDB tables: 804M (Tables: 14358)
[--] Data in PERFORMANCE_SCHEMA tables: 0B (Tables: 52)
[--] Data in MEMORY tables: 0B (Tables: 222)
[!!] Total fragmented tables: 651

-------- Security Recommendations  -------------------------------------------
[OK] All database users have passwords assigned

-------- Performance Metrics -------------------------------------------------
[--] Up for: 2h 59m 17s (1M q [130.468 qps], 38K conn, TX: 4B, RX: 529M)
[--] Reads / Writes: 69% / 31%
[--] Total buffers: 500.0M global + 2.6M per thread (1024 max threads)
[OK] Maximum possible memory usage: 3.1G (40% of installed RAM)
[OK] Slow queries: 0% (248/1M)
[OK] Highest usage of available connections: 10% (107/1024)
[OK] Key buffer size / total MyISAM indexes: 256.0M/976.3M
[OK] Key buffer hit rate: 98.9% (3M cached / 40K reads)
[OK] Query cache efficiency: 66.8% (664K cached / 994K selects)
[!!] Query cache prunes per day: 308893
[OK] Sorts requiring temporary tables: 0% (19 temp sorts / 32K sorts)
[!!] Joins performed without indexes: 1072
[!!] Temporary tables created on disk: 32% (17K on disk / 52K total)
[OK] Thread cache hit rate: 99% (241 created / 38K connections)
[!!] Table cache hit rate: 14% (7K open / 51K opened)
[OK] Open file limit used: 18% (9K/50K)
[OK] Table locks acquired immediately: 99% (494K immediate / 495K locks)
[!!] InnoDB  buffer pool / data size: 128.0M/804.2M
[OK] InnoDB log waits: 0
-------- Recommendations -----------------------------------------------------
General recommendations:
    Run OPTIMIZE TABLE to defragment tables for better performance
    MySQL started within last 24 hours - recommendations may be inaccurate
    Adjust your join queries to always utilize indexes
    When making adjustments, make tmp_table_size/max_heap_table_size equal
    Reduce your SELECT DISTINCT queries without LIMIT clauses
    Increase table_open_cache gradually to avoid file descriptor limits
    Read this before increasing table_open_cache over 64: /http://www.mysqlperformanceblog.com/2009/11/16/table_cache-negative-scalability/
Variables to adjust:
    query_cache_size (> 75M)
    join_buffer_size (> 1.0M, or always use indexes with joins)
    tmp_table_size (> 80M)
    max_heap_table_size (> 25M)
    table_open_cache (> 7500)
    innodb_buffer_pool_size (>= 804M)

MySQL 5.6 Optimization Guidance

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