Mysql High CPU Optimization help

Hello and good Day. Sorry for my bad English. My Server is running very poorly. I have a high CPU utilization. (80%-95%) I ask for Help. Processor Information:

Total processors: 4 
Vendor
        GenuineIntel
Name
        Intel(R) Core(TM) i3-3220 CPU @ 3.30GHz
Speed
        3300.000 MHz
Cache
        3072 KB

My my.cnf

[mysqld]
max_allowed_packet=268435456
open_files_limit=10000

 >>  MySQLTuner 1.4.0 - Major Hayden 
 >>  Bug reports, feature requests, and downloads at http://mysqltuner.com/
 >>  Run with '--help' for additional options and output filtering
[OK] Currently running supported MySQL version 5.6.21
[OK] Operating on 64-bit architecture

-------- Storage Engine Statistics -------------------------------------------
[--] Status: +ARCHIVE +BLACKHOLE +CSV -FEDERATED +InnoDB +MRG_MYISAM
[--] Data in MyISAM tables: 1G (Tables: 831)
[--] Data in InnoDB tables: 5M (Tables: 273)
[--] Data in PERFORMANCE_SCHEMA tables: 0B (Tables: 52)
[--] Data in MEMORY tables: 496K (Tables: 8)
[!!] Total fragmented tables: 35

-------- Security Recommendations  -------------------------------------------
[OK] All database users have passwords assigned

-------- Performance Metrics -------------------------------------------------
[--] Up for: 4d 6h 44m 39s (32M q [88.579 qps], 1M conn, TX: 1419B, RX: 38B)
[--] Reads / Writes: 83% / 17%
[--] Total buffers: 169.0M global + 1.1M per thread (151 max threads)
[OK] Maximum possible memory usage: 338.9M (5% of installed RAM)
[OK] Slow queries: 0% (309/32M)
[OK] Highest usage of available connections: 54% (83/151)
[OK] Key buffer size / total MyISAM indexes: 8.0M/529.4M
[OK] Key buffer hit rate: 99.5% (2B cached / 10M reads)
[!!] Query cache is disabled
[OK] Sorts requiring temporary tables: 0% (2K temp sorts / 826K sorts)
[!!] Joins performed without indexes: 15296
[OK] Temporary tables created on disk: 1% (4K on disk / 364K total)
[OK] Thread cache hit rate: 97% (36K created / 1M connections)
[!!] Table cache hit rate: 10% (1K open / 15K opened)
[OK] Open file limit used: 20% (2K/10K)
[OK] Table locks acquired immediately: 99% (85M immediate / 85M locks)
[OK] InnoDB buffer pool / data size: 128.0M/5.6M
[OK] InnoDB log waits: 0
-------- Recommendations -----------------------------------------------------
General recommendations:
    Run OPTIMIZE TABLE to defragment tables for better performance
    Adjust your join queries to always utilize indexes
    Increase table_open_cache gradually to avoid file descriptor limits
    Read this before increasing table_open_cache over 64: http://bit.ly/1mi7c4C
Variables to adjust:
    query_cache_type (=1)
    join_buffer_size (> 256.0K, or always use indexes with joins)
    table_open_cache (> 2000)

        -- MYSQL PERFORMANCE TUNING PRIMER --
             - By: Matthew Montgomery -

MySQL Version 5.6.21 x86_64

Uptime = 4 days 6 hrs 34 min 35 sec
Avg. qps = 88
Total Questions = 32710667
Threads Connected = 11

Server has been running for over 48hrs.
It should be safe to follow these recommendations

To find out more information on how each of these
runtime variables effects performance visit:
http://dev.mysql.com/doc/refman/5.6/en/server-system-variables.html
Visit http://www.mysql.com/products/enterprise/advisors.html
for info about MySQL's Enterprise Monitoring and Advisory Service

SLOW QUERIES
The slow query log is NOT enabled.
Current long_query_time = 10.000000 sec.
You have 309 out of 32710725 that take longer than 10.000000 sec. to complete
Your long_query_time seems to be fine

BINARY UPDATE LOG
The binary update log is NOT enabled.
You will not be able to do point in time recovery
See http://dev.mysql.com/doc/refman/5.6/en/point-in-time-recovery.html

WORKER THREADS
Current thread_cache_size = 9
Current threads_cached = 4
Current threads_per_sec = 0
Historic threads_per_sec = 0
Your thread_cache_size is fine

MAX CONNECTIONS
Current max_connections = 151
Current threads_connected = 7
Historic max_used_connections = 83
The number of used connections is 54% of the configured maximum.
Your max_connections variable seems to be fine.

INNODB STATUS
Current InnoDB index space = 7 M
Current InnoDB data space = 5 M
Current InnoDB buffer pool free = 74 %
Current innodb_buffer_pool_size = 128 M
Depending on how much space your innodb indexes take up it may be safe
to increase this value to up to 2 / 3 of total system memory

MEMORY USAGE
Max Memory Ever Allocated : 246 M
Configured Max Per-thread Buffers : 169 M
Configured Max Global Buffers : 153 M
Configured Max Memory Limit : 322 M
Physical Memory : 6.00 G
Max memory limit seem to be within acceptable norms

KEY BUFFER
Current MyISAM index space = 529 M
Current key_buffer_size = 8 M
Key cache miss rate is 1 : 215
Key buffer free ratio = 0 %
You could increase key_buffer_size
It is safe to raise this up to 1/4 of total system memory;
assuming this is a dedicated database server.

QUERY CACHE
Query cache is enabled
Current query_cache_size = 1 M
Current query_cache_used = 16 K
Current query_cache_limit = 1 M
Current Query cache Memory fill ratio = 1.64 %
Current query_cache_min_res_unit = 4 K
Your query_cache_size seems to be too high.
Perhaps you can use these resources elsewhere
MySQL won't cache query results that are larger than query_cache_limit in size

SORT OPERATIONS
Current sort_buffer_size = 256 K
Current read_rnd_buffer_size = 256 K
Sort buffer seems to be fine

JOINS
Current join_buffer_size = 260.00 K
You have had 15288 queries where a join could not use an index properly
You should enable "log-queries-not-using-indexes"
Then look for non indexed joins in the slow query log.
If you are unable to optimize your queries you may want to increase your
join_buffer_size to accommodate larger joins in one pass.

Note! This script will still suggest raising the join_buffer_size when
ANY joins not using indexes are found.

OPEN FILES LIMIT
Current open_files_limit = 10000 files
The open_files_limit should typically be set to at least 2x-3x
that of table_cache if you have heavy MyISAM usage.
Your open_files_limit value seems to be fine

TABLE CACHE
Current table_open_cache = 2000 tables
Current table_definition_cache = 1400 tables
You have a total of 1193 tables
You have 1581 open tables.
The table_cache value seems to be fine

TEMP TABLES
Current max_heap_table_size = 16 M
Current tmp_table_size = 16 M
Of 363784 temp tables, 1% were created on disk
Created disk tmp tables ratio seems fine

TABLE SCANS
Current read_buffer_size = 128 K
Current table scan ratio = 34 : 1
read_buffer_size seems to be fine

TABLE LOCKING
Current Lock Wait ratio = 1 : 1370
You may benefit from selective use of InnoDB.
If you have long running SELECT's against MyISAM tables and perform
frequent updates consider setting 'low_priority_updates=1'
If you have a high concurrency of inserts on Dynamic row-length tables
consider setting 'concurrent_insert=ALWAYS'.

Thanks in advance for your Help.

Mysql High CPU Optimization help

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